Recent Highlights

1. Megli, CJ, DePuyt, AE, Goff, JP, Munyoki, SK, Hooven, TA, Jašarević, E, “Diet influences community dynamics following vaginal group B streptococcus colonization.” Microbiology Spectrum 12, e0362323. 2024.

2. Bhavana, VH, Hillebrand, GH, Gopalakrishna, KP, Rapp, RA, Ratner, AJ, Tettelin, H, Hooven, TA. “A group B Streptococcus indexed transposon mutant library to accelerate genetic research on an important perinatal pathogen.” Microbiology Spectrum 11, e02046-23. 2023.

3. Gopalakrishna, KP, Hillebrand, GH, Bhavana, VH, Elder, JL, D’mello, A, Tettelin, H, Hooven, TA. “Group B Streptococcus Cas9 variants provide insight into programmable gene repression and CRISPR-Cas transcriptional effects.” Communications Biology. 2023, 6(620) [* equal contribution to authorship].

4. Keith, MF, Gopalakrishna, KP, Bhavana, VH, Hillebrand, GH, Elder, JL, Megli, CJ, Sadovsky, Y, Hooven, TA. “Nitric oxide production and effects in group B Streptococcus chorioamnionitis.” Pathogens. 2022, 11(1115).

5. Lin, YC, Salleb-Aouissi, A, Hooven, TA. “Interpretable prediction of necrotizing enterocolitis from machine learning analysis of premature infant stool microbiota.” BMC Bioinformatics. 2022, 23(104).

6. Dammann, AN, Chamby, AB, Gonzalez, FJ, Sharp, ME, Flores, K, Shahi, I, Dongas, S, Hooven, TA, Ratner, AJ. “Group B Streptococcus capsular serotype alters vaginal colonization fitness.” Journal of Infectious Diseases. 2021, doi:10.1093/infdis/jiab559.

7. Kim G-L, Hooven TA, Norambuena J, Li B, Boyd JM, Yang JH, Parker D. “Growth and stress tolerance comprise independent metabolic strategies critical for Staphylococcus aureus Infection.” mBio. 2021, 12: e00814-21.

8. Dammann AN, Chamby AB, Catomeris AJ, Davidson KM, Tettelin H, van Pijkeren J-P, Gopalakrishna KP, Keith MF, Elder JL, Ratner AJ, Hooven TA. “Genome-wide fitness analysis of group B Streptococcus in human amniotic fluid reveals a transcription factor that controls multiple virulence traits.” PLOS Pathogens. 2021, 17(3): e1009116.

9. Hooven TA, Lin YC, Salleb-Aouissi A. “Multiple instance learning for predicting necrotizing enterocolitis in premature infants using microbiome data.” Proceedings of the ACM Conference on Health, Inference, and Learning (ACM CHIL ’20), April 2–4, 2020, Toronto, ON, Canada.

10. Hooven TA, Bonakdar M, Chamby AB, Ratner AJ. “A counterselectable sucrose sensitivity marker permits efficient and flexible mutagenesis in Streptococcus agalactiae.” Applied and Environmental Microbiology. 2019, 85(7).

12. Hooven TA, Catomeris AJ, Bonakdar M, Tallon LJ, Tettelin H, Ratner AJ. “The Streptococcus agalactiae stringent response enhances virulence and persistence in human blood.” Infection and Immunity. 2017, 86(1): e00612–17.

13. Hooven TA, Catomeris AJ, Akabas LH, Randis TM, Maskell DJ, Peters SE, Ott S, Santana-Cruz I, Tallon LJ, Tettelin H, Ratner AJ. “The essential genome of Streptococcus agalactiae.” BMC Genomics. 2016, 17(1): 406-419.

Screen Shot 2020-01-27 at 2.57.03 PM.png

Screen Shot 2020-01-27 at 2.55.01 PM.png

Screen Shot 2020-01-27 at 2.57.14 PM.png

Screen Shot 2020-01-27 at 2.56.25 PM.png

Screen Shot 2020-01-27 at 2.56.36 PM.png

Screen Shot 2020-01-27 at 2.56.15 PM.png

Screen Shot 2020-01-27 at 2.55.23 PM.png

Screen Shot 2020-01-27 at 2.56.50 PM.png

Screen Shot 2020-01-27 at 2.55.59 PM.png

Screen Shot 2020-01-27 at 2.57.26 PM.png