Studies

 

The Hooven lab is seeking undergraduates, graduate students, residents, and clinical fellows seeking research training experiences. Several ongoing projects that present opportunities for involvement include:

 
 
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Bacterial evolution in disease models

  • Mouse models of persistent colonization

  • Transmission from mother to infant

  • Immune selection for virulence traits


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GBS sensing of host inducers of virulence

  • Free radical induction of toxicity

  • Fetoplacental signals affecting GBS invasion

  • Microbiome factors


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Construction of complete mutant libraries

  • High-throughput techniques

  • Comprehensive pathway dissection

  • Multiplex competition assays

 

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CRISPR tools for studying infection

  • Rapid generation of gene knockdowns

  • Novel tools for drug target discovery

  • Protein-protein interactions


 
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